CBD reduces cocaine addiction
Researchers from Pompeu Fabra University (UPF) have shown that CBD (cannabidiol) can be useful in reducing the addictive effects of cocaine.
This research has been published in the journal Neuropharmacology and was carried out by the Behavioral Neurobiology Research Group. (GReNeC-NeuroBio) and allows us to better understand the role of this cannabis derivative (CBD) in the signaling pathways underlying its consumption.
The study was conducted on cocaine-addicted mice that voluntarily self-administered a dose of the drug by pressing a lever. It was found that administering CBD to the mice reduced their voluntary cocaine consumption. It is worth noting that cannabidiol is a substance derived from cannabis with no addictive potential.
CBD as a therapeutic tool
Olga Valverde, a researcher in the Department of Experimental and Health Sciences (DCEXS), stated: “Our study provides new evidence on the potential use of cannabidiol as a therapeutic tool. Furthermore, it has allowed us to better understand the modulating role of this compound in the signaling pathways underlying cocaine use.”.
The researcher also highlighted that at the molecular level, CBD "can modulate some manifestations of cocaine reinforcement," increasing the expression of neurotrophic factors (proteins that promote the survival of neurons) through a mechanism involving CB1 cannabinoid receptors and promoting the proliferation of new cells in the hippocampus or brain area related to memory.
This discovery is important because there are no effective treatments for cocaine addiction, making it necessary to develop new therapeutic strategies, especially given that cocaine is the second most consumed illicit drug in Europe and the United States.
Fountain: SINC
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